Milo is a casual user of recreational substances. Unfortunately this makes him an unreliable sort, so when his best friend (Blake Harrison - Inbetweeners) is getting married he rules Milo out as Best Man. As a result, Milo does some (more) drugs to get over this disappointment.
Milo discovers that he and his buddy are being hunted by a killer from an alternate universe. Their only hope is to jump into other universes, like in Sliders but even more chaotic and humourous. Okay, they may end up jumping at random with no control over their destination, but at least there is an ongoing story-line with a recurring villain.
The guys arrive in a world where Milo is a sad mummy's boy and his buddy is an suit-wearing office worker. It seems that their lives only worked out properly in the real world because the two of them were best of friends. In the other worlds, where they were not friends, things went badly for them.
The guys arrive in a world where Milo is a Rock Star and his buddy is an anorak-wearing obsessive fan. Unfortunately the local Milo is missing, presumed suicided, but this just means everyone is eager to accept him back. Georgina Campbell is his manager-cum-GF.
There is a down side to the world, or at least a different side. Nigel Farage has been elected Prime Minister, and because he decriminalised hand-guns everyone carries one. However, the guns turn out to be very useful. Also, the local version of the mad killer is actually quite helpful.